HuGENavigator|HuGE Risk Translator

HuGE Navigator (version 1.4)
An integrated, searchable knowledge base of genetic associations and human genome epidemiology.

HuGE Risk Translator

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Gene
Disease

One Risk Genotype
Two Risk Genotypes

Risk Genotype 1
Name
Frequency(%)
Odds Ratio

Risk Genotype 2
Name
Frequency(%)
Odds Ratio

Reference Genotype
Name
Frequency(%)
Odds Ratio

Disease Risk(%)

Enter required information including the frequency of the risk variant, the population disease risk and the odds ratio between the gene and disease.
Switch one genotype view or two genotype view by clicking the radio button.
Two genotype information are required if using Two Genotype view.
Change Search dropdown list to switch to other HuGE Navigator applications.

HuGE Risk Translator is a tool to help evaluate the predictive ability of genetic markers by calculating a variety of indicators in epidemiology, clinical validity & utility and public health.

Finding a genetic association is only the first step towards translation to population health benefits. Whether a genetic marker can yield a useful predictive test depends on the frequency of the risk genotype, the disease risk in the population and the strength of the association between the genetic marker and the occurrence of disease.

These indicators include the genotype-specific disease risks, the sensitivity and specificity of the genetic test and the population attributable fraction, among others. The indicators can be calculated when the frequency of the risk variant, the population disease risk and the odds ratio between the gene and disease are known.

How to cite this site:
Wei Yu, Cecile Janssens, Marta Gwinn and Muin J. Khoury. HuGE Risk Translator. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/checkerComplexStartPage.do. Accessed [date of access].